Vanadium in PDB 8k7c: Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound)

All present enzymatic activity of Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound):
7.6.2.5;

The structure of Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound) also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Vanadium atom in the Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound) (pdb code 8k7c). This binding sites where shown within 5.0 Angstroms radius around Vanadium atom.
In total 2 binding sites of Vanadium where determined in the Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound), PDB code: 8k7c:
Jump to Vanadium binding site number: 1; 2;

Vanadium binding site 1 out of 2 in the Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound)


Mono view


Stereo pair view

A full contact list of Vanadium with other atoms in the V binding site number 1 of Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound) within 5.0Å range: probe atom residue distance (Å) B Occ A:V902 b:121.1 occ:1.00 V A:VO4902 0.0 121.1 1.0 O3 A:VO4902 1.9 121.1 1.0 O1 A:VO4902 1.9 121.1 1.0 O4 A:VO4902 1.9 121.1 1.0 O2 A:VO4902 1.9 121.1 1.0 O2B A:ADP901 3.0 102.4 1.0 NE2 A:GLN671 3.2 97.3 1.0 PB A:ADP901 3.4 102.4 1.0 O1B A:ADP901 3.5 102.4 1.0 O3B A:ADP901 3.5 102.4 1.0 NE2 A:HIS783 3.7 109.1 1.0 MG A:MG903 3.9 119.8 1.0 CD2 A:HIS783 4.3 109.1 1.0 CD A:GLN671 4.4 97.3 1.0 N B:GLY730 4.6 93.8 1.0 NZ A:LYS629 4.6 97.4 1.0 O B:ALA756 4.6 104.5 1.0 CE A:LYS629 4.7 97.4 1.0 OE1 A:GLN671 4.8 97.3 1.0 C B:GLY729 4.8 96.7 1.0 CE1 A:HIS783 4.8 109.1 1.0 CA B:GLY729 4.8 96.7 1.0 O3A A:ADP901 4.9 102.4 1.0

Vanadium binding site 2 out of 2 in the Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound)


Mono view


Stereo pair view

A full contact list of Vanadium with other atoms in the V binding site number 2 of Outward-Facing Structure of Human ABCB6 W546A Mutant (Adp/VO4-Bound) within 5.0Å range: probe atom residue distance (Å) B Occ B:V902 b:106.5 occ:1.00 V B:VO4902 0.0 106.5 1.0 O2 B:VO4902 1.9 106.5 1.0 O4 B:VO4902 1.9 106.5 1.0 O3 B:VO4902 1.9 106.5 1.0 O1 B:VO4902 1.9 106.5 1.0 O1B B:ADP901 2.7 99.4 1.0 PB B:ADP901 3.0 99.4 1.0 NE2 B:HIS783 3.0 109.5 1.0 O3B B:ADP901 3.2 99.4 1.0 O2B B:ADP901 3.2 99.4 1.0 CE1 B:HIS783 3.6 109.5 1.0 NE2 B:GLN671 3.8 90.5 1.0 MG B:MG903 3.9 100.3 1.0 CD2 B:HIS783 4.2 109.5 1.0 N A:GLY730 4.3 95.0 1.0 C A:GLY729 4.5 94.9 1.0 CB B:SER625 4.5 106.5 1.0 O3A B:ADP901 4.6 99.4 1.0 CA A:GLY730 4.7 95.0 1.0 CA A:GLY729 4.7 94.9 1.0 CA B:SER625 4.8 106.5 1.0 ND1 B:HIS783 4.9 109.5 1.0

S.S.Lee, J.G.Park, E.Jang, S.H.Choi, S.Kim, J.W.Kim, M.S.Jin. W546 Stacking Disruption Traps the Human Porphyrin Transporter ABCB6 in An Outward-Facing Transient State. Commun Biol V. 6 960 2023.
ISSN: ESSN 2399-3642
PubMed: 37735522
DOI: 10.1038/S42003-023-05339-3