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Atomistry » Vanadium » PDB 7q0v-9f6c » 9f6c | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Vanadium » PDB 7q0v-9f6c » 9f6c » |
Vanadium in PDB 9f6c: Cardiac Myosin Motor Domain in the Pre-Powerstroke State Co- Crystallized with the Inhibitor AficamtenProtein crystallography data
The structure of Cardiac Myosin Motor Domain in the Pre-Powerstroke State Co- Crystallized with the Inhibitor Aficamten, PDB code: 9f6c
was solved by
J.Robert-Paganin,
J.J.Hartman,
B.P.Morgan,
F.I.Malik,
A.Houdusse,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 9f6c:
The structure of Cardiac Myosin Motor Domain in the Pre-Powerstroke State Co- Crystallized with the Inhibitor Aficamten also contains other interesting chemical elements:
Vanadium Binding Sites:
The binding sites of Vanadium atom in the Cardiac Myosin Motor Domain in the Pre-Powerstroke State Co- Crystallized with the Inhibitor Aficamten
(pdb code 9f6c). This binding sites where shown within
5.0 Angstroms radius around Vanadium atom.
In total 2 binding sites of Vanadium where determined in the Cardiac Myosin Motor Domain in the Pre-Powerstroke State Co- Crystallized with the Inhibitor Aficamten, PDB code: 9f6c: Jump to Vanadium binding site number: 1; 2; Vanadium binding site 1 out of 2 in 9f6cGo back to Vanadium Binding Sites List in 9f6c
Vanadium binding site 1 out
of 2 in the Cardiac Myosin Motor Domain in the Pre-Powerstroke State Co- Crystallized with the Inhibitor Aficamten
Mono view Stereo pair view
Vanadium binding site 2 out of 2 in 9f6cGo back to Vanadium Binding Sites List in 9f6c
Vanadium binding site 2 out
of 2 in the Cardiac Myosin Motor Domain in the Pre-Powerstroke State Co- Crystallized with the Inhibitor Aficamten
Mono view Stereo pair view
Reference:
J.J.Hartman,
D.T.Hwee,
J.Robert-Paganin,
C.Chuang,
E.R.Chin,
S.Edell,
K.H.Lee,
R.Madhvani,
P.Paliwal,
J.Pernier,
S.S.Sarkar,
J.Schaletzky,
K.Schauer,
K.D.Taheri,
J.Wang,
E.Wehri,
Y.Wu,
A.Houdusse,
B.P.Morgan,
F.I.Malik.
Aficamten Is A Small-Molecule Cardiac Myosin Inhibitor Designed to Treat Hypertrophic Cardiomyopathy Nat Cardiovasc Res V. 3 1003 2024.
Page generated: Fri Oct 11 20:47:44 2024
ISSN: ESSN 2731-0590 DOI: 10.1038/S44161-024-00505-0 |
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