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Vanadium in PDB 8tgs: The Crystal Structure of the Post-Reactive State of Udp-Sugar Pyrophosphorylase From Leishmania Major in Complex with Product Udp- Glucose and By-Product Analog VO4 (Orthovanadate)

Enzymatic activity of The Crystal Structure of the Post-Reactive State of Udp-Sugar Pyrophosphorylase From Leishmania Major in Complex with Product Udp- Glucose and By-Product Analog VO4 (Orthovanadate)

All present enzymatic activity of The Crystal Structure of the Post-Reactive State of Udp-Sugar Pyrophosphorylase From Leishmania Major in Complex with Product Udp- Glucose and By-Product Analog VO4 (Orthovanadate):
2.7.7.64;

Protein crystallography data

The structure of The Crystal Structure of the Post-Reactive State of Udp-Sugar Pyrophosphorylase From Leishmania Major in Complex with Product Udp- Glucose and By-Product Analog VO4 (Orthovanadate), PDB code: 8tgs was solved by O.Prakash, J.I.Fuehring, P.Baruch, F.H.Routier, R.Fedorov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 59.07 / 2.20
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 108.08, 122.42, 61.24, 90, 105.55, 90
R / Rfree (%) 21.1 / 24.2

Other elements in 8tgs:

The structure of The Crystal Structure of the Post-Reactive State of Udp-Sugar Pyrophosphorylase From Leishmania Major in Complex with Product Udp- Glucose and By-Product Analog VO4 (Orthovanadate) also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Vanadium Binding Sites:

The binding sites of Vanadium atom in the The Crystal Structure of the Post-Reactive State of Udp-Sugar Pyrophosphorylase From Leishmania Major in Complex with Product Udp- Glucose and By-Product Analog VO4 (Orthovanadate) (pdb code 8tgs). This binding sites where shown within 5.0 Angstroms radius around Vanadium atom.
In total only one binding site of Vanadium was determined in the The Crystal Structure of the Post-Reactive State of Udp-Sugar Pyrophosphorylase From Leishmania Major in Complex with Product Udp- Glucose and By-Product Analog VO4 (Orthovanadate), PDB code: 8tgs:

Vanadium binding site 1 out of 1 in 8tgs

Go back to Vanadium Binding Sites List in 8tgs
Vanadium binding site 1 out of 1 in the The Crystal Structure of the Post-Reactive State of Udp-Sugar Pyrophosphorylase From Leishmania Major in Complex with Product Udp- Glucose and By-Product Analog VO4 (Orthovanadate)


Mono view


Stereo pair view

A full contact list of Vanadium with other atoms in the V binding site number 1 of The Crystal Structure of the Post-Reactive State of Udp-Sugar Pyrophosphorylase From Leishmania Major in Complex with Product Udp- Glucose and By-Product Analog VO4 (Orthovanadate) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:V701

b:98.7
occ:0.80
V A:VO4701 0.0 98.7 0.8
O4 A:VO4701 1.9 74.0 0.8
O3 A:VO4701 1.9 84.3 0.8
O2 A:VO4701 1.9 78.8 0.8
O1 A:VO4701 1.9 93.3 0.8
NH1 A:ARG401 3.9 68.3 1.0
NZ A:LYS220 4.2 67.2 1.0
MG A:MG702 4.3 78.5 0.9
CE A:LYS220 4.7 69.1 1.0
CD A:LYS220 4.9 64.3 1.0

Reference:

O.Prakash, J.I.Fuehring, P.Baruch, F.H.Routier, R.Fedorov. The Post-Reactive State Structures of Leishmania Major Udp-Sugar Pyrophosphorylase Provide Insights Into the Product Release Mechanism To Be Published.
Page generated: Sun Feb 9 00:01:16 2025

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