Vanadium in PDB 8cvh: Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine

Enzymatic activity of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine

All present enzymatic activity of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine:
1.14.11.11;

Protein crystallography data

The structure of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine, PDB code: 8cvh was solved by E.W.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	43.75 / 2.03
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	44.915, 79.102, 56.276, 90, 111.25, 90
*R / R_free (%)*	20.1 / 25

Other elements in 8cvh:

The structure of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine also contains other interesting chemical elements:

Strontium

(Sr)

2 atoms

Vanadium Binding Sites:

The binding sites of Vanadium atom in the Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine (pdb code 8cvh). This binding sites where shown within 5.0 Angstroms radius around Vanadium atom.
In total only one binding site of Vanadium was determined in the Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine, PDB code: 8cvh:

Vanadium binding site 1 out of 1 in 8cvh

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Vanadium Binding Sites List in 8cvh

Vanadium binding site 1 out of 1 in the Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine

Mono view

Stereo pair view

A full contact list of Vanadium with other atoms in the V binding site number 1 of Structure of L289F Hyoscyamine 6-Beta Hydroxylase in Complex with Vanadyl, Succinate, and 6-Oh-Hyoscyamine within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:V414 b:21.6 occ:1.00	O	A:HOH502	1.6	28.0	1.0
	OD1	A:ASP219	2.1	19.2	1.0
	NE2	A:HIS273	2.1	20.9	1.0
	NE2	A:HIS217	2.2	17.2	1.0
	O	A:HOH501	2.2	19.7	0.9
	O1	A:SIN408	2.5	27.0	0.9
	O2	A:SIN408	2.8	30.6	0.9
	C1	A:SIN408	3.0	29.2	0.9
	CE1	A:HIS217	3.1	17.5	1.0
	CD2	A:HIS273	3.1	21.2	1.0
	CG	A:ASP219	3.1	18.9	1.0
	CE1	A:HIS273	3.2	21.4	1.0
	CD2	A:HIS217	3.2	18.0	1.0
	OD2	A:ASP219	3.4	19.1	1.0
	O1	A:OVR409	3.6	43.8	1.0
	ND1	A:HIS217	4.2	17.1	1.0
	CG	A:HIS273	4.2	20.9	1.0
	ND1	A:HIS273	4.2	21.1	1.0
	CG	A:HIS217	4.3	17.9	1.0
	CB	A:ASP219	4.5	18.9	1.0
	C2	A:SIN408	4.5	28.8	0.9
	CE2	A:PHE289	4.5	19.1	1.0
	C6	A:OVR409	4.6	41.6	1.0
	C7	A:OVR409	4.6	42.4	1.0
	ND2	A:ASN255	4.7	24.8	1.0
	CZ	A:PHE289	4.8	19.3	1.0
	N	A:ASP219	4.8	18.8	1.0
	CA	A:ASP219	4.8	18.4	1.0

Reference:

E.S.Wenger, A.K.Boal, J.M.Bollinger, C.Krebs. Structure of the L289F H6H Cyclization Ferryl-Mimicking Complex To Be Published.

Page generated: Thu Dec 28 12:02:53 2023

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