Vanadium in PDB 6npz: Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate

All present enzymatic activity of Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate:
2.7.11.1;

The structure of Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate, PDB code: 6npz was solved by N.Chu, P.A.Cole, S.B.Gabelli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.82 / 2.12
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	86.321, 56.088, 92.019, 90.00, 104.56, 90.00
R / Rfree (%)	18.5 / 24.1

The structure of Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate also contains other interesting chemical elements:

Manganese

(Mn)

4 atoms

The binding sites of Vanadium atom in the Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate (pdb code 6npz). This binding sites where shown within 5.0 Angstroms radius around Vanadium atom.
In total only one binding site of Vanadium was determined in the Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate, PDB code: 6npz:

Vanadium binding site 1 out of 1 in the Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate


Mono view


Stereo pair view

A full contact list of Vanadium with other atoms in the V binding site number 1 of Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate within 5.0Å range: probe atom residue distance (Å) B Occ B:V502 b:20.0 occ:1.00 V B:VO4502 0.0 20.0 1.0 O4 B:VO4502 1.8 20.0 1.0 O3 B:VO4502 1.8 20.0 1.0 O1 B:VO4502 1.8 20.0 1.0 O2 B:VO4502 1.8 20.0 1.0 O B:HOH739 4.0 45.0 1.0 O B:HOH608 4.1 40.1 1.0 O B:HOH785 4.6 34.9 1.0

N.Chu, A.L.Salguero, A.Z.Liu, Z.Chen, D.R.Dempsey, S.B.Ficarro, W.M.Alexander, J.A.Marto, Y.Li, L.M.Amzel, S.B.Gabelli, P.A.Cole. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell V. 174 897 2018.
ISSN: ISSN 1097-4172
PubMed: 30078705
DOI: 10.1016/J.CELL.2018.07.003