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Vanadium in PDB 5jnw: Crystal Structure of Bovine Low Molecular Weight Protein Tyrosine Phosphatase (Lmptp) Mutant (W49Y N50E) Complexed with Vanadate and Uncompetitive Inhibitor

Enzymatic activity of Crystal Structure of Bovine Low Molecular Weight Protein Tyrosine Phosphatase (Lmptp) Mutant (W49Y N50E) Complexed with Vanadate and Uncompetitive Inhibitor

All present enzymatic activity of Crystal Structure of Bovine Low Molecular Weight Protein Tyrosine Phosphatase (Lmptp) Mutant (W49Y N50E) Complexed with Vanadate and Uncompetitive Inhibitor:
3.1.3.48;

Protein crystallography data

The structure of Crystal Structure of Bovine Low Molecular Weight Protein Tyrosine Phosphatase (Lmptp) Mutant (W49Y N50E) Complexed with Vanadate and Uncompetitive Inhibitor, PDB code: 5jnw was solved by S.M.Stanford, A.E.Aleshin, R.C.Liddington, L.Bankston, G.Cadwell, N.Bottini, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.70 / 1.86
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 60.347, 125.493, 45.251, 90.00, 90.00, 90.00
R / Rfree (%) 16.6 / 21

Vanadium Binding Sites:

The binding sites of Vanadium atom in the Crystal Structure of Bovine Low Molecular Weight Protein Tyrosine Phosphatase (Lmptp) Mutant (W49Y N50E) Complexed with Vanadate and Uncompetitive Inhibitor (pdb code 5jnw). This binding sites where shown within 5.0 Angstroms radius around Vanadium atom.
In total only one binding site of Vanadium was determined in the Crystal Structure of Bovine Low Molecular Weight Protein Tyrosine Phosphatase (Lmptp) Mutant (W49Y N50E) Complexed with Vanadate and Uncompetitive Inhibitor, PDB code: 5jnw:

Vanadium binding site 1 out of 1 in 5jnw

Go back to Vanadium Binding Sites List in 5jnw
Vanadium binding site 1 out of 1 in the Crystal Structure of Bovine Low Molecular Weight Protein Tyrosine Phosphatase (Lmptp) Mutant (W49Y N50E) Complexed with Vanadate and Uncompetitive Inhibitor


Mono view


Stereo pair view

A full contact list of Vanadium with other atoms in the V binding site number 1 of Crystal Structure of Bovine Low Molecular Weight Protein Tyrosine Phosphatase (Lmptp) Mutant (W49Y N50E) Complexed with Vanadate and Uncompetitive Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:V201

b:30.3
occ:1.00
V A:VO4201 0.0 30.3 1.0
O1 A:VO4201 1.8 24.0 1.0
O2 A:VO4201 1.9 27.1 1.0
O3 A:VO4201 1.9 26.3 1.0
SG A:CYS12 2.5 24.8 1.0
CB A:CYS12 3.5 20.7 1.0
N A:GLY14 3.8 25.5 1.0
N A:ARG18 3.8 21.0 1.0
N A:CYS17 3.8 24.2 1.0
NH2 A:ARG18 3.9 25.9 1.0
NE A:ARG18 3.9 22.3 1.0
C8 A:6LJ202 4.0 22.2 0.2
C8 A:6LJ202 4.0 22.2 0.2
C7 A:6LJ202 4.1 22.4 0.2
C7 A:6LJ202 4.1 22.7 0.2
CB A:CYS17 4.1 25.3 1.0
N A:ASN15 4.1 24.7 1.0
N A:LEU13 4.2 27.8 1.0
CA A:CYS17 4.3 24.8 1.0
N A:ILE16 4.3 24.5 1.0
CA A:GLY14 4.3 27.4 1.0
CZ A:ARG18 4.4 24.7 1.0
C A:CYS17 4.5 22.5 1.0
CB A:ARG18 4.5 19.8 1.0
C A:GLY14 4.6 24.5 1.0
C A:CYS12 4.6 24.4 1.0
CA A:CYS12 4.7 22.5 1.0
CA A:ARG18 4.7 20.4 1.0
SG A:CYS17 4.7 28.0 1.0
CG A:ARG18 4.7 18.4 1.0
OD1 A:ASP129 4.8 23.6 1.0
CA A:ASN15 4.8 24.5 1.0
C A:LEU13 4.8 31.7 1.0
CA A:LEU13 4.8 29.5 1.0
CB A:LEU13 4.9 30.0 1.0
C A:ILE16 4.9 23.6 1.0
N A:SER19 5.0 20.5 1.0

Reference:

S.M.Stanford, A.E.Aleshin, V.Zhang, R.J.Ardecky, M.P.Hedrick, J.Zou, S.R.Ganji, M.R.Bliss, F.Yamamoto, A.A.Bobkov, J.Kiselar, Y.Liu, G.W.Cadwell, S.Khare, J.Yu, A.Barquilla, T.D.Y.Chung, T.Mustelin, S.Schenk, L.A.Bankston, R.C.Liddington, A.B.Pinkerton, N.Bottini. Diabetes Reversal By Inhibition of the Low-Molecular-Weight Tyrosine Phosphatase. Nat. Chem. Biol. V. 13 624 2017.
ISSN: ESSN 1552-4469
PubMed: 28346406
DOI: 10.1038/NCHEMBIO.2344
Page generated: Thu Oct 29 07:05:52 2020

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