Vanadium in PDB 3s3f: Crystal Structure of the Catalytic Domain of PTP10D From Drosophila Melanogaster with A Small Molecule Inhibitor Vanadate

Enzymatic activity of Crystal Structure of the Catalytic Domain of PTP10D From Drosophila Melanogaster with A Small Molecule Inhibitor Vanadate

All present enzymatic activity of Crystal Structure of the Catalytic Domain of PTP10D From Drosophila Melanogaster with A Small Molecule Inhibitor Vanadate:
3.1.3.48;

Protein crystallography data

The structure of Crystal Structure of the Catalytic Domain of PTP10D From Drosophila Melanogaster with A Small Molecule Inhibitor Vanadate, PDB code: 3s3f was solved by L.L.Madan, B.Gopal, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	39.68 / 2.70
*Space group*	P 3₁ 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	103.070, 103.070, 173.401, 90.00, 90.00, 120.00
*R / R_free (%)*	23.8 / 27.2

Vanadium Binding Sites:

The binding sites of Vanadium atom in the Crystal Structure of the Catalytic Domain of PTP10D From Drosophila Melanogaster with A Small Molecule Inhibitor Vanadate (pdb code 3s3f). This binding sites where shown within 5.0 Angstroms radius around Vanadium atom.
In total only one binding site of Vanadium was determined in the Crystal Structure of the Catalytic Domain of PTP10D From Drosophila Melanogaster with A Small Molecule Inhibitor Vanadate, PDB code: 3s3f:

Vanadium binding site 1 out of 1 in 3s3f

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Vanadium Binding Sites List in 3s3f

Vanadium binding site 1 out of 1 in the Crystal Structure of the Catalytic Domain of PTP10D From Drosophila Melanogaster with A Small Molecule Inhibitor Vanadate

Mono view

Stereo pair view

A full contact list of Vanadium with other atoms in the V binding site number 1 of Crystal Structure of the Catalytic Domain of PTP10D From Drosophila Melanogaster with A Small Molecule Inhibitor Vanadate within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:V308 b:0.9 occ:1.00	V	B:VO4308	0.0	0.9	1.0
	O4	B:VO4308	1.9	0.4	1.0
	O1	B:VO4308	1.9	0.4	1.0
	O2	B:VO4308	1.9	0.6	1.0
	O3	B:VO4308	1.9	0.1	1.0
	CB	B:SER243	3.7	28.7	1.0
	NZ	B:LYS154	4.1	41.6	1.0
	N	B:SER243	4.1	26.0	1.0
	N	B:ALA244	4.4	26.6	1.0
	CA	B:SER243	4.4	26.7	1.0
	SG	B:CYS242	4.5	26.7	1.0
	OG	B:SER243	4.6	30.5	1.0
	NE	B:ARG248	4.7	28.4	1.0
	CB	B:CYS242	4.7	26.0	1.0
	O	B:HOH358	4.8	30.0	1.0
	C	B:SER243	4.9	26.3	1.0
	CD	B:ARG248	4.9	26.3	1.0
	OE1	B:GLN286	5.0	42.2	1.0

Reference:

L.L.Madan, B.Gopal. Conformational Basis For Substrate Recruitment in Protein Tyrosine Phosphatase 10D Biochemistry V. 50 10114 2011.
ISSN: ISSN 0006-2960
PubMed: 22007620
DOI: 10.1021/BI201092Q

Page generated: Fri Oct 11 19:28:08 2024

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