Vanadium in PDB 2b9s: Crystal Structure of Heterodimeric L. Donovani Topoisomerase I- Vanadate-Dna Complex

All present enzymatic activity of Crystal Structure of Heterodimeric L. Donovani Topoisomerase I- Vanadate-Dna Complex:
5.99.1.2;

The structure of Crystal Structure of Heterodimeric L. Donovani Topoisomerase I- Vanadate-Dna Complex, PDB code: 2b9s was solved by D.R.Davies, W.G.J.Hol, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.48 / 2.27
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	72.433, 106.102, 126.691, 90.00, 90.00, 90.00
R / Rfree (%)	23.1 / 27.5

The binding sites of Vanadium atom in the Crystal Structure of Heterodimeric L. Donovani Topoisomerase I- Vanadate-Dna Complex (pdb code 2b9s). This binding sites where shown within 5.0 Angstroms radius around Vanadium atom.
In total only one binding site of Vanadium was determined in the Crystal Structure of Heterodimeric L. Donovani Topoisomerase I- Vanadate-Dna Complex, PDB code: 2b9s:

Vanadium binding site 1 out of 1 in the Crystal Structure of Heterodimeric L. Donovani Topoisomerase I- Vanadate-Dna Complex


Mono view


Stereo pair view

A full contact list of Vanadium with other atoms in the V binding site number 1 of Crystal Structure of Heterodimeric L. Donovani Topoisomerase I- Vanadate-Dna Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:V301 b:20.9 occ:1.00 V B:VO4301 0.0 20.9 1.0 O1 B:VO4301 1.7 22.8 1.0 O2 B:VO4301 1.8 19.4 1.0 O3' C:DT10 1.8 24.5 1.0 O5' D:DA11 2.0 23.7 1.0 OH B:TYR222 2.1 22.5 1.0 C5' D:DA11 2.9 22.1 1.0 C3' C:DT10 3.0 23.9 1.0 CZ B:TYR222 3.1 23.9 1.0 CE1 B:TYR222 3.3 22.9 1.0 C4' C:DT10 3.4 22.5 1.0 NH2 A:ARG314 3.7 19.9 1.0 NE A:ARG314 4.0 19.8 1.0 NE A:ARG410 4.0 25.2 1.0 NH2 A:ARG410 4.1 25.0 1.0 O B:HOH304 4.1 24.9 1.0 C2' C:DT10 4.1 23.1 1.0 NE2 A:HIS453 4.2 25.9 1.0 NZ A:LYS352 4.2 20.4 1.0 C4' D:DA11 4.2 22.6 1.0 O B:HOH303 4.3 19.6 1.0 CZ A:ARG314 4.3 21.2 1.0 CE2 B:TYR222 4.3 24.0 1.0 C1' C:DT10 4.4 21.8 1.0 O4' C:DT10 4.4 25.2 1.0 C5' C:DT10 4.5 21.6 1.0 CZ A:ARG410 4.5 25.5 1.0 CD1 B:TYR222 4.6 21.5 1.0 O4' D:DA11 4.7 22.1 1.0 CD A:LYS352 5.0 21.2 1.0

D.R.Davies, A.Mushtaq, H.Interthal, J.J.Champoux, W.G.Hol. The Structure of the Transition State of the Heterodimeric Topoisomerase I of Leishmania Donovani As A Vanadate Complex with Nicked Dna. J.Mol.Biol. V. 357 1202 2006.
ISSN: ISSN 0022-2836
PubMed: 16487540
DOI: 10.1016/J.JMB.2006.01.022